Protein Details: Glutamate receptor ionotropic; kainate 2

Protein ID

ICDB_Pro_0008

Protein Name

Glutamate receptor ionotropic; kainate 2

Gene Name

grik2

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Length

908 amino acids

AlphaFoldDB

AF-A0A2R8QF68-F1-model_v4.pdb

Function

Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel; gated by L-glutamate and the glutamatergic agonist kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change; leading to the opening of the cation channel; and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state; characterized by the presence of bound agonist. Independent of its ionotropic glutamate receptor activity; acts as a thermoreceptor conferring sensitivity to cold temperatures. Functions in dorsal root ganglion neurons (By similarity).

Sequence

MQRIAGITKMVTHRRWLGLLLLLLCVGYSHGMPHVLRFGGIFESIESGPSGAEELAFKFALNTINRNRTLLPNTTLTYDIQRINIHDSFEASRKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTKWKHQVSDNRDSFYVNLYPDFSSLSRAILDLVHFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNIRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCGHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENSQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVAVAVQQSPQITVSSLQCNRHKPWRFGNRFMTLIKEAHWDGLTGRINFNRTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTENQKGKTANVTDSLSNRSLVVSTILEEPYVMFKKSDKPLYGNDRFEGYCVDLLRELAAILGFGYELRLVEDGRYGAQDESSGQWNGMVRELMDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGVVEDGSTMTFFKKTKISTYDKMWEFMSSRRHSVMVKSIEEGIERVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKAYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEENKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKQNAQLEKRSFCSAMVDELRVSLKCQRRLKHKPQPPVMVKTDEVINMHTFNDRRLPGKETMA

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 516; /ligand="L-glutamate"; BINDING 518; /ligand="L-glutamate"; BINDING 523; /ligand="L-glutamate"; BINDING 689; /ligand="L-glutamate"; BINDING 690; /ligand="L-glutamate"; BINDING 738; /ligand="L-glutamate"

Disease

Location

DOI ID

10.1038/nature12111; 10.1016/j.cell.2019.07.034